Current Issue : April - June Volume : 2014 Issue Number : 2 Articles : 8 Articles
In present work, ANN (Artificial Neural Network) is compared with MRA (Multiple Regression Analysis) for their ability to predict effect of formulation parameters on product characteristics or responses. \r\nMethodology: Two factors three level full factorial design was employed for preparation of nine batches of Albendazole solid lipid Nano-particle. Lipid (Compritol ââ?¬â??ATO 888) to drug ration and amount of surfactant (Poloxamer-188) ware selected as factor X1 and X2 respectively. Besides the factorial batches, four check point batches were also prepared. Particle size and % Entrapment Efficiency (%EE) were selected as responses Y1 and Y2 respectively.\r\n ANN and MRA models were developed from result of nine factorial batches. Responses of all check point batches were predicted using both models individually. Chi-square test was performed between predicted and actual responses of both models. \r\n Response surface graphs were developed for the optimization purpose. From 3D surfaces, optimized formulation with minimum particle size and maximum %EE was selected.\r\nResult: Result data of this work conclude that, both methods are equally efficient for their prediction efficiency. However, this conclusion is not universal, ANN can be versatile model for prediction purpose. More work should be welcomed to support this result....
The aim of present study is to formulations of NLC loaded nanoparticles for treatment of patients with psoriasis. This novel formulation of Halobetasol Propionate was prepared by using both solid lipid and liquid lipid with different concentration of surfactant by high pressure homogenization method.NLC were characterized for particle size, polydispersity index (PDI), zeta potential, entrapment efficiency and In vitro release. Surface morphology was determined by Scanning electron Microscopy (SEM). NLC based gel was characterized for pH, Spredability, drug content, stability study. Stability study was carried out for 3 month. It indicated no significant change in particle size, Zeta Potential, PDI, drug content and drug release. \r\nKeywords: Halobetasol propionate, psoriasis, NLC etc....
Topically applied remedies provide release of drugs directly at the pathological site and provide a number of advantages over conventional methods of drug administration. Miconazole Nitrate has good antifungal activity. The aim of study was to design and evaluation of miconazole nitrate microsponge for sustained release topical drug delivery system by quasi-emulsion diffusion method. The average size of microsponge formulation is less than 300�µm. So it has good patient compliance. Microsponge formulation has ability to improve bioavailability and solubility of poorly soluble drug. The Miconazole Nitrate microsponge were prepared by using Eudragit RS100 as a polymer, Polyvinyl alcohol as an emulsifying agent, Triethyl citrate as a plasticizer, Dichloro methane and methanol used as solvent. \r\nFor the optimization of Miconazole Nitrate loaded microsponge Central Composite Design was employed. Process variable like Speed (X1), PVA concentration (X2), Drug: Polymer Ratio (X3) was defined as factors, where as Loading Efficiency (Y1), Production Yield (Y2), Drug Content (Y3) and Particle Size (Y4) and Cumulative percentage release (Y5). The optimized batch of Miconazole Nitrate loaded microsponge was evaluated by Particles size, shape and internal structure by SEM. Compatibility was evaluated by FTIR of optimized batch. In vitro dissolution study of miconazole nitrate microsponge confirmed that it gives sustained release effect up to 12 hour. Kinetic models of formulation confirmed that, it follows zero order kinetic. The optimized batch of microsponge was incorporated in to carbopol 934 gel, and it showed desired drug content, in vitro diffusion, spreadability, pH and viscosity as per standard criteria....
The aim of this study was to development and characterize press coated tablet of Diacerein and Aceclofenac. The drug delivery system was based on the concept of chronotherapeutics. Dosage form provides delayed release up to 6 h and after completion of lag time up to 6 h dosage form provides burst release of drugs therefore highest blood level of the drugs coincide with pain which occurs particularly at specific period of time during day cycle Drug polymer compatibility studies were carried out by FT-IR. If one drug is act as DMARD (Disease Modifying Anti Rheumatic Drug) and other drug act as NSAID ( Non Steroidal Anti Inflammatory Drug) this combination has well established effect on arthritis. Here, Diacerein act as DMARD and Aceclofenac act as NSAID therefore Diacerein and Aceclofenac combination has been used for obtaining synergistic effect on treatment of arthrities. Core tablet was prepared by direct compression using superdisintegrants sodium starch glycolate. The core tablet was compression coated with different quantities of coating material containing different polymers. A 32 Full factorial design was used for optimization of barrier layer. Total coat weight (X1) and % HPMC K4M (X2) were selected as independent variables. The lag time for Diacerein (Y1), CPR at 1 st hr after lagtime for Diacerein (Y2), time for 90% drug release for Diacerein (Y3), the lag time for Aceclofenac (Y4), CPR at 1st hr after lagtime for Aceclofenac (Y5) and time for 90% drug release for Aceclofenac (Y6) were selected as dependent variables. Tablets were evaluated for various evaluation parameters. Comparative dissolution profiles of all the batches indicate drug release from tablet was inversely proportional to coat weight. From release profile it also found that delay lag time was observed for the press-coated tablet containing a higher amount of HPMC K4M in the outer shell. The press coated tablets coated with HPMC K4M:HPMC K100 in 64.39:35.61 ratios with 200 mg coat weight are most likely to provide desired delivery of Diacerein and Aceclofenac....
As drug delivery systems Nanoparticles are widely investigated because of many advantages such as smaller size, controlled drug release potential, targeting ability, enhancement of therapeutic efficacy and reduction of toxicity. This article describes the development of solid lipid nanoparticles (SLN) as colloidal carriers for Nifedipine. Nifedipine is an antihypertensive drug with poor oral bioavailability ranging about 10 to 20% due to first pass metabolism. The present study was undertaken to investigate the lipid nature of Dynasan-116 (Tripalmitin) on Nifedipine loaded solid lipid nanoparticles using hot homogenization ultrasonication method. Poloxamer-188 was used as surfactant. The prepared SLNs were characterized for particle size, polydispersity index (PDI), zeta potential, entrapment efficiency (EE) and invitro drug release studies. The invitro characterization of nifedipine loaded SLN was performed in 0.1NHCl and pH6.8 phosphate buffer using dialysis bag method. Differential Scanning Calorimetry (DSC) studies were conducted to characterize the state of drug and lipid modification....
Floating dosage forms of Verapamil Hydrochloride, used for its anti-anginal and antihypertensive effect, were developed to prolong gastric residence time and increase bioavailability. Present investigation describes the influence of Hydroxypropyl Methylcellulose (HPMC) polymer viscosity and Gas generating agent (GGA) on Verapamil Hydrochloride release from floating matrix tablets. Tablets were prepared using wet granulation technique and were evaluated for in-vitro floating ability and % drug release study. Dissolution profiles were subjected for various kinetic treatments to analyze the release pattern of the drug and result found that drug release by diffusion mechanism. The study shows that tablet composition has great influence on the floating properties and drug release under in-vitro dissolution conditions, the addition of GGA to Verapamil Hydrochloride sustained-release tablets modifies the matrix hydration volume which have important role in drug diffusion. Floating ability was dependent on the amount of effervescent agent and gel-forming polymer of the floating layer. Drug release was prolonged to 12 hours by changing the type and viscosity of the matrix-forming polymer in the drug-loading layer and all formulations showed a diffusion release mechanisms. From the result, it was observed that the kinetics of drug release mainly dependent on viscosity of HPMC and it was modified by incorporation of gas generating agent....
A considerable portion (40%) of drugs fail full development, because of Poor water solubility of drug molecules, insufficient bioavailability, fluctuating plasma levels and high food dependency. Itraconazole is one of such agent, a poorly water soluble drug indicates insufficient bioavailability following oral administration. The purpose of the present study was to formulate and optimize Itraconazole nanosuspension. In the present work Itraconazole nanosuspension was prepared by pearl milling technique using zirconium oxide beads as a milling media. A series of polymers and surfactants were screened and finally HPC-EF as a polymer and SDS were finalized. To optimize formulation parameters, 33 factorial design was adopted. Effects of various process parameters like, stirring time and the ratio of the beads were optimized using final formulation. The optimized nanosuspension was lyophilized using mannitol (1:1 ratio) as a cryoprotectant. Nanosuspension was characterized by particle size and size distribution, drug content, scanning electron microscopy, differential scanning colorimetry and its dissolution profile was compared with marketed product. Optimized nanosuspension showed spherical shape with surface oriented surfactant molecules and a mean particle diameter of 302 nm. There was no significant change in crystalline nature after formulation and it was found to be chemically stable with high drug content.The in vitro dissolution profile of the optimized formulation compared to the pure drug and marketed formulation (Canditral Capsule) by using 0.1N Hydrochloric acid as release medium showed higher drug release.\r\nKeywords: Nanosuspension, Itraconazole, Pearl milling technique, optimization...
The objective of this study was to detect nabumetone cocrystals by use of DSC and FTIR tools and identify potential cocrystal formers from its large numbers which can be functional for further dosage development. Nabumetone cocrystals were prepared at molar stoichiometric ratio with cocrystal former by solvent evaporation and subsequently vaccum dried at 50�°C. Eight out of the thirty tested formed cocrystals with nabumetone viz. Salicylic acid, benzoic acid, m-hydroxy benzoic acid, cinnamic acid, malonic acid, glutaric acid, maleic acid and ferulic acid. We have applied the utility of DSC and FTIR for rapid nabumetone cocrystal screening which encourages use of number cocrystal formers for given set of experiment. The detected new phase can be further transformed to develop bioequivalent dosage as like parent form or even improved one...
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